Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2113 | 2113-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | A62V, V75I, K219N | L100I, K103N | K43E, A98S, V118I, K122E, I135V, H208Y, L228H, V245E |
| >2113-30819| codons 38-247 CTELEEEGKISKIGPENPYNTPVFVIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHP SGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQYLWRWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, I84V, L90M | G73C | L10I, T12P, I13V, I15V, K20I, E35E_G, M36I, R41K, D60E, Q61D, I62V, L63P, C67Y | T31I |
| >2113-30819| codons 4-99 TLWQRPIVPVKVGGQLIEALLDTGADDIVLEEINLPGKWKPKIVGGIGGFLKVRQYEDVP IEIYGHKAICTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |