Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2112 | 2112-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54L, V82A, I84V | L10H, I13V, L19V, K20I, I62V, L63T, I64V, T74S, T91A | V11P |
| >2112-30813| codons 4-99 TLWQRPHPTVKIGGQVIEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGFLKVRQYDQVT VEICGHKAIGSVLVGPTPANVIGRNLLAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219W | L100I, K103N | A98G | V60I, S68I, T69H, V118I, K122E, I135T, Q174QK, D177E, G196E, T200I, I202V, H208Y, D218E, E224D, L228H |
| >2112-30813| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNIHRWRKLVDFRELNKRTQDFWEVQLGIPHP GGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPEIVIYQYVDDLYVGSDLEIEQHRIKVEELRQYLLRWGFFTP EWKHQKDPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |