Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2110 | 2110-30709 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | V11VI, L24I, L33F | L10V, I13V, K14R, I15V, L19LP, K20T, E35D, M36V, R41K, L63P, I64V, A71V, V77I, I93L |
| >2110-30709| codons 4-99 TLWQRPVITVRVGGQPTEALIDTGADDTVFEDVNLPGKWKPKLIGGIGGFVKVRQYDQIP VEICGHKVIGTVLIGPTPVNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | V75VA, K219R | F227FL | K43KQ, E44D, V118I, K122E, I135T, E203K, Q207E, H208Y, R211K, K223E, V245K | V106T |
| >2110-30709| codons 38-246 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVADFRELNKRTQDFWEVQLGIPHP AGLKKKKSTTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP DRKHQEEPPLLWMGYELHPDKWTVQPIKL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |