Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2108 | 2108-30619 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, I84V | L10I, I15V, K20R, M36I, N37D, K43S, Q61QK, I62V, L63C, H69R, A71V, I72T, T74AS, I93L |
| >2108-30619| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEEIDLPGRWSPKIIGGIGGFVKVRQYDKVC IEICGRKVTGSVVVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V, T215F | K219Q | Y181C, G190A | K101H, V108I | K49Q, A98S, D123E, Q174R, D177E, I178L, V189I, G196E, F214L, D218E |
| >2108-30619| codons 38-247 CTEMEKEGKISQIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLHKKKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKRNPELVICQYVDDLYIASDLEIEQHRTKIEELRQHLLRWGLFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |