<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1178 1178-30625 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, T215Y K219R K103N V108I T39TA, K43N, E44D, D123E, Q174QR, D177EG, E203K, Q207E, H208Y, R211RK, K223E, L228H, V245T  
>1178-30625| codons 38-247
CAELENDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKRNPGIVIYQYVDDLYVGSDLEIGQHRTKIKELREYLLKWGFYTP
DRKHQEEPPFHWMGYELHPDKWTVQPITLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46ML, I54V, V82A, L90M L33F, F53FL L10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63AT, A71V, I93L G94GD
>1178-30625| codons 4-99
TLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKLIGGIGGLVKVRQYEQVT
IEICGHKVIGTVLVGPTPANIIGRNLMTQLDCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006