Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2324 | 2324-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V, L90M | Q58E | L10I, L19IT, K20R, E35D, M36I, K55R, D60E, I62IV, L63P |
| >2324-30724| codons 4-99 TLWQRPIVTIKIGGQTREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVRVREYEQVP IEICGHKAIGTVLVGPTPFNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | Y188L | K43E, E44A, V118I, K122E, I142IV, S162SA, V179I, T200A, E203K, H208Y, R211K, K223E, L228H |
| >2324-30724| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIGQHRAKIKELRQYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |