Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2322 | 2322-30722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | Y181C, G190A | V179E | K43E, K103R, D123E, I135T, I202V |
| >2322-30722| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIEICQYVDDLYVASDLEIGQHRTKVEELRQHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F, K43T, G73S | L10V, I15IV, K20KR, E35ED, M36L, N37D, I62V, L63P, C67F, A71V, I72K, C95L |
| >2322-30722| codons 4-99 TLWQRPVVTIKVGGQLREALLDTGADDTVFEDLDLPGRWTPKLIGGIGGFVKVRQYDQVP IEIFGHKVKSTVLVGPTPANIIGRNLMTQIGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |