Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2203 | 2203-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184MV, L210W, T215Y | K219R | P225PH | K43Q, K82KR, A98S, V118I, K122E, V189VI, E203D, R211K, L228H |
| >2203-30708| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNRRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYIGSDLEIGQHRTKIDELRQHLWKWGFYTP DRKHQKEHPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I47IV, I54IV, I84V, L90M | G73T | L10I, K20R, E35D, M36I, N37T, L38LM, I62V, L63P, A71IV, V77I, I93L |
| >2203-30708| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTILEDITMPGRWKPKMVGGIGGFVKVRQYDQVP IEICGHKVITTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |