Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1503 | 1503-30619 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219N | K103N, Y181C, G190A | K43Q, K64R, K101Q, L109I, V118I, D121H, K122E, I135T, E138EQ, V189I, G196E, I202V, H208Y, R211RK, D218E |
| >1503-30619| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSVTVIDVGDAYFSIPLHEDFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYIASDLEIEQHRTKVEELRQYLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, G48M, I54M, V82A | L33F, F53L | L10V, K14R, G16E, K20R, E35D, M36I, K43I, K55R, R57K, I62V, L63S, A71V, I72V |
| >1503-30619| codons 4-99 TLWQRPVVTIRIEGQLREALLDTGADDTIFEDINLPGRWIPKIVMGIGGLMRVKQYDQVS IEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |