Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2300 | 2300-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K103N, Y181YC | A98G | V60I, V90I, I135T, S162W, V179VI, T200K, Q207E, R211K, F214FL, D218E, L228H |
| >2300-30819| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQWSMTKILEPFRKQNPDIIICQYVDDLYVGSDLEIGQHRKKIEELREHLLKWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | L24I, L33F | L10I, T12P, N37S, K55R, I62IV, L63P, K70T, A71V, V77I |
| >2300-30819| codons 4-99 TLWQRPIVPIKIGGQLKEALIDTGADDTVFEEMSLPGRWKPKLIGGIGGFVRVRQYDQVP IEICGHTVIGTVLIGPTPVNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |