Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2234 | 2234-31205 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 19 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219E | Y188L | F227FL | E44D, W88WC, V118I, K122E, D123E, R172K, D177E, I178L, E194N, G196E, I202V, E203EK, H221Y, A272P, K277R, E297K, S322T, I326V, G333E, Q334N, G335S, R356K, R358RK, S379C |
| >2234-31205| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPELVI YQYVDDLLVGSDLNIEQHRTKVKELRQHLWRWGFYTPDEKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQENSQWTYQIYQEPFKNLKTGKYAKMKGA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82T, L90M | N88D | L10I, I15V, K20R, E35D, M36I, N37D, I62V, L63P, A71V, F99Y |
| >2234-31205| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVIGTVLVGPTPTNIIGRDLMTQIGCTLNY |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |