Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 143P11 | 143P11W72 | U.S. | 1993 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 40 |
| 2 | DDI | 72 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, L74V | K219KQ | D121H, K122E, I142V, R172X, Q174X, I178M, V179I, R211K, K238X |
| >143P11W72| codons 26-240 LTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKRKDSTRWRKVVDFRELNKRTQ DFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETPGVRYQ YNVLPQGWKGSPAIFQSSMTKILEPFXKXNPDMIIYQYMDDLYVGSDLEIGQHRTKIEEL RQHLLKWGFTTPDQKHQKEPPFLWMGYELHPDXWT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| W6X, Q7X, E35D, K45Q, L63P |
| >143P11W72| codons 1-99 PQITLXXRPLVTIKIGGQLKEALLDTGADDTVLEDMNLPGRWKPQMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Winters, MA | Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. | AAC, 1997 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |