<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2234 2234-30722 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82T, L90M L10FI, N88D I15V, K20R, E35D, M36I, N37D, I62V, L63P, A71V, F99Y  
>2234-30722| codons 4-99
TLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFVKVRQYDQVP
IEICGHKVIGTVLVGPTPTNIIGRDLMTQIGCTLNY

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219KN     E44D, R83RK, K102KQ, V118I, K122E, D123E, D177E, I178L, E194N, G196E, I202IV, H208HY, K223KQ  
>2234-30722| codons 38-247
CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGIPHP
AGLKQKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPELVIYQYVDDLYVGSDLNIEQHRTKVEELRQYLWRWGFYTP
DNKHQQEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006