Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2437 | 2437-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | A62V, K70S, V75I, F116Y | K101E, Y181C, G190A | V108I | S68N, V90I, V118VI, K122E, D123E, I135IR, T139TA, T165I, T200A, Q207E, F214L |
| >2437-30820| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDNTSWRKLIDFRELNKRTQDFWEIQLGIPHP AGLEKKKSVTILDVGDAYYSIPLDEEFRKYTAFTIPSRNNEAPGIRYQYNVLPMGWKGSP AIFQSSMIKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIEELREHLLRWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, I84V, L90M | L10FY, G73C | K20I, E34Q, M36I, R41K, K43E, Q61N, I62V, L63P, I64V, C67W, I72T, P79A, I85V, Q92K, I93L | D60EGKR |
| >2437-30820| codons 4-99 TLWQRPYVTIKIGGQLIEALLDTGADDTVLQEINLPGKWEPKMIGGIGGFMKVRQYRNVP VEIWGHKATCTVLVGATPVNVVGRNLMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |