Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1486 | 1486-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46L, I54LV, L90M | L33F, G73IS | L10I, I13S, I15V, K20R, E35D, M36I, R41K, I62V, L63P, K70E, A71V, I93L |
| >1486-30819| codons 4-99 TLWQRPIVTSKVGGQLREALLDTGADDTIFEDINLPGKWKPKLIGGIGGFVKVRQYDQVP IEICGHEVISTVLVGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103N | V60VI, V90VI, V118I, K122E, I135T, Q174R, I178IL, E203EK, Q207DE, H208HY, R211K |
| >1486-30819| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDLVIYQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |