Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1485 | 1485-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, L90M | L10I, D60E, I62IV, L63P, I64L, A71T, I72V, V77I |
| >1485-30818| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFMKVRQYEQVP LEICGHKTVGTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | V106VA | F227FL | T39TA, K49KR, V60I, V118VI, D121Y, K122E, S162C, D177E, I178L, G196E | S105SL |
| >1485-30818| codons 38-247 CAELEKEGKISRIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKLATVLDVGDAYFSIPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPELVIYQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTP DNKHQKEPPLLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |