Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1481 | 1481-30812 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54V, L90M | L10F, N88D | E35D, M36I, N37S, R41K, I62V, L63P, A71T, I72M, I93L |
| >1481-30812| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADNTVLEDISLPGKWKPKMIGGIGGFVKVRQYDQVP IEICGHKTMGTVLVGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V106A, G190A | F227L | E44D, E53D, V118I, K122E, I195T, E203K, H208Y, R211Q, K223E |
| >1481-30812| codons 38-247 CTELEKDGKISKIGPDNPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSATVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLETGQHRTKIKELRQYLWQWGFYTP DKKHQEEPPLLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |