Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2480 | 2480-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184V, T215FV | D67G, K219Q | K103N, Y181C | K64H, V118I, I135T, T200A, Q207E, F214L, L228HR, V245T |
| >2480-30822| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKGSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGLVTP DQKHQKEPPFRWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | L33F, F53L | L10V, I13V, I15V, M36ML, R41N, L63P, K70R, A71V |
| >2480-30822| codons 4-99 TLWQRPVVTVKVGGQLKEALLDTGADDTIFEELNLPGNWKPKIIGGIGGLVKVRQYDQIP IEICGHRVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |