Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1285 | 1285-30311 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V, L90M | N83D | L10I, K20R, E34Q, R41K, D60E, I62V, L63P, A71V, I93L | M36D_* |
| >1285-30311| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLQEDNLPGKWKPKIIGGIGGFLKVRQYEQVP IEICGHKVIGTVVVGPTPVDVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67S, K219E | L100I, K103N | I50V, T69N, K122E, I135T, Q174R, T200A, R211G, F214L, L228H, V245K |
| >1285-30311| codons 38-247 CTEMEKEGKISKVGPENPYNTPVFAIKKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLGWGLFTP DEKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |