Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1463 | 1463-30603 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215Y | K219E | Y181YC | K101H | T39TA, V118VI, K122E, D123S, I135T, E169D, V179I, I202V, H208Y, L228LHR |
| >1463-30603| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIIICQYVDDLYVGSDLEIGQHRTKVEELRQYLLRWGFYTP DEKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L10I, T12K, L19I, K20I, E34Q, N37S, R41RK, L63P, C67CF, H69HQ, I72IL, G73I, V77I |
| >1463-30603| codons 4-99 TLWQRPIVKIKIGGQIIEALLDTGADDTILQEMSLPGKWKPKIVGGIGGFMKVRQYDQIP IEIFGQKALITVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |