Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1720 | 1720-30520 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181C | T39E, S68G, V111I, K122E, I135T, K166R, I178LM, V179VI, G196E, T200TAIV, H208Y, R211K, L228H |
| >1720-30520| codons 38-247 CEELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDMIICQYVDDLYVGSDLEIEQHRVKIEELRQYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, V11I, F53L, G73C | T12P, I15V, L19P, K20I, E35D, M36I, N37E, I62V, L63P, I64V, A71V, I72IT, T74S, I85V, T91S, I93L |
| >1720-30520| codons 4-99 TLWQRPFIPIKVGGQPIEALLDTGADDTVLEDIELPGRWKPKIIGGIGGLIKVRQYDQVP VEICGHKVTCSVLVGPTPVNVVGRNLMSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |