Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2391 | 2391-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I47IV, I54IL, I84IV, L90M | Q58E | I15IV, G16E, K20R, E35D, M36I, N37E, L63P, A71V, P79PH, I93L |
| >2391-30813| codons 4-99 TLWQRPLVTIKVEGQLREALLDTGADDTILEDIELPGRWKPKIVGGIGGFLKVREYDQIP IEICGHKVIGTVLVGHTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LV, M184MV, L210W, T215Y | K219N | K103KN | E44D, V60I, W88C, V118I, L120*, K122E, D123N, D177E, G196E, E203K, Q207D, H208Y, R211K |
| >2391-30813| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFCEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIP*DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRTKIKELRDYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |