Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2230 | 2230-30709 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, N37S, L63T, I72T, V77I, I93L |
| >2230-30709| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQIT IEICGHKATGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70KE, V75M, L210W, T215Y | D67E | K103S, G190A | K238T | T39A, E44D, S68G, K122E, S134G, E203D, Q207E, H208Y, R211K, V245K |
| >2230-30709| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKEGTEWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIGQHRTKIDELREYLWKWGFYTP DKKHQKEPPFLWMGYELHPDTWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |