Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2101 | 2101-30618 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IL, V82A, I84V | L24I, L33F | L10I, T12P, R41K, K43I, K55R, Q61E, I62V, L63P, I66IV, A71T, I72T, I93IL | D60H |
| >2101-30618| codons 4-99 TLWQRPIVPIKIGGQLKEALIDTGADDTVFEEMNLPGKWIPKIIGGIGGFLRVRQYHEVP IEVCGHKTTGTVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | D123E, I135V, D177E, T200E | S68SDGN |
| >2101-30618| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDNTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHREKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |