<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2099 2099-30613 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, K219N K101E, Y181C, G190AS V108I K43E, E44A, T69N, L109I, V118I, K122E, I135T, G196E, H208Y, R211K, D218E, H221Y  
>2099-30613| codons 38-247
CTELEEAGKISKIGPENPYNTPVFAIKKKNSNKWRKLMDFRELNKRTQDFWEVQLGIPHP
AGLEKKKSVTIIDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVSSDLEIEQHRTKIEELRQYLWKWGFYTP
ENKYQKEPPFLWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, I84V, L90M V11IL, G73S, L89V L10Y, I13V, K20V, L38W, I62V, L63P, A71IV  
>2099-30613| codons 4-99
TLWQRPYLTVKIGGQLVEALLDTGADDTILEEMNWPGRWKPKIVGGIGGFMKVRQYDQVP
IEICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006