Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1139 | 1139-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215FY | F77FL | L100I, K103N | E44D, I50IM, D121H, K122E, S162C, Q174R, D177E, G196E, Q207E, R211K, V245E | H235HD |
| >1139-30318| codons 38-247 CTELEKDGKISKMGPENPYNTPVFAIKKKNSTKWRKVVDLRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKRNPEIVIYQYMDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELDPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82VA, L90M | L33F, F53L, G73NS, L89V | L10I, I13V, E34EQ, R41K, K43R, I62IV, L63P, H69Y, A71V, V77I, I93L |
| >1139-30318| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTIFQEMNLPGKWRPKIVGGIGGLMKVRQYDQVP IEICGYKVISTVLIGPTPANIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |