Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2494 | 2494-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11VI, L33F, F53L, G73T | L10I, I13V, G16A, K20R, L24F, M36MIL, R41K, K55R, I62V, L63P, A71V, I72T |
| >2494-30821| codons 4-99 TLWQRPIITVKIAGQLREALFDTGADDTVFEELNLPGKWKPKLIGGIGGLVRVRQYDQVP IEICGHKVTTTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, Y115F, M184V, L210W, T215Y | A62V, V75S | Y181C | A98G, E138EDKN | T58N, S68G, K122E, S134SG, V179I, R211K, H221Y |
| >2494-30821| codons 38-247 CTELEKEGKISKIGPENPYNNPVFVIKKKDGTKWRKISDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPGINNNTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |