Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1842 | 1842-30731 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, V75I, F116Y, K219E | L100I, K103N | S68G, T69TA, K102R, K122E, T139A, G196E, V245E |
| >1842-30731| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDGAKWRKLIDFRELNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNEAPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTP DEKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, I84V, L90M | L33F, T74P | L10I, I13V, G16A, K20R, E34Q, M36I, N37D, R41K, I62V, L63P, A71V, I72T, I93L |
| >1842-30731| codons 4-99 TLWQRPIVTVKIAGQLREALLDTGADDTVFQEIDLPGKWKPKMIGGIGGFLKVRQYDQVP IEICGHKVTGPVLVGPTPANVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |