Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1840 | 1840-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A | L33F, K43T | I13V, K20R, M36ML, L63P, A71T, I72E, I93L |
| >1840-30724| codons 4-99 TLWQRPLVTVKIGGQLREALLDTGADDTIFEELNLPGRWTPKIVGGIGGFLKVRQYDQIP IEICGHKTEGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K103N | V60VI, V118I, K122E, K166KR, V179VI, T200A, Q207E, V245K |
| >1840-30724| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |