Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1838 | 1838-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, G73S | L10I, T12TP, I15V, K20T, I62V, L63P, I66F, C67Y, H69Q, A71V, I72L, V77VI |
| >1838-30715| codons 4-99 TLWQRPIVPIKVGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYDQVP IEFYGQKVLSTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219Q | K101E, Y181C, G190S | A98G | K43Q, E44D, K64KR, V111VIM, V118I, D123E, S162SN, K166Q, D177E, H208Y, R211K, D218E, L228H |
| >1838-30715| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTVLDMGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTQILEPFRKQNPEIVICQYVDDLYVSSDLEIGQHRTKIEELRQYLWKWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |