Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1836 | 1836-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54T, V82S | K43KT | L10I, K20R, E35D, M36I, N37E, I62V, L63A, A71V, T74S, V77I, I93L |
| >1836-30710| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWTPKIIVGIGGFTKVRQYDQVA IEICGHKVIGSVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74I, M184V, L210W, T215F | K219Q | K101KPQT, K103NS | T39LS, V118VI, K122E, S162SN, D177N, T200TI, R211K, D218E, L228H |
| >1836-30710| codons 38-247 CSELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLTKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIGQHRIKIEELRQHLWKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |