Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2161 | 2161-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82CG, I84IV, L90M | F53FL, Q58QE | L10I, V11L, I13V, K20V, K55KR, I62V, L63P, A71V, Q92QKR |
| >2161-30708| codons 4-99 TLWQRPILTVKIGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLVRVREYDQVP IEICGHKVIGTVLVGPTPGNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, T215F | K219Q | K103N, Y181C | V60I, K101R, K122E, I135T, I167V, G196E, D218E |
| >2161-30708| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLRKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPDIVICQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |