Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1418 | 1418-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54IV, V82AT, L90M | V11I, L33I, K43IMT, F53L, L89V | L10V, I13V, K14T, L19T, K20T, E35D, M36I, N37D, K55R, R57K, D60N, I62V, L63P, I66IL, C67L, H69Q, A71I |
| >1418-30820| codons 4-99 TLWQRPVITVTIGGQTTEALLDTGADDTIIEDIDLPGRWTPKIVGGIGGLVRVKQYNQVP IELLGQKIIGTVLVGPTPTNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_ES, M184V, L210W, T215F | A62V | Y181C, G190A | A98AG | V106VI, K122P, Q174R, I178L, V179I, G196E, Q197K, T200A, E203D, Q207E, R211K, L228H, V245M |
| >1418-30820| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSITVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDLIICQYVDDLYVASDLEIEKHRAKIDELREHLWKWGFFTP DKKHQKEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |