Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2272 | 2272-30804 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | L10F, L33F, Q58E, G73S, L89V | V11VL, K14KR, I15V, L19I, K20V, M36I, D60E, I62V, L63P, H69KQ, V77I, I85V |
| >2272-30804| codons 4-99 TLWQRPFLTIRVGGQIVEALLDTGADDTIFEEINLPGRWKPKIVGGIGGFIKVREYEQVP IEICGQKAISTVLIGPTPVNIVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210GW, T215CY | K219E | Y188L | A98G | E44D, V60I, K122E, V179I, T200A, I202V, H208Y, R211K, W212M, L228H, V245E |
| >2272-30804| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIGQHRAKVEELRQYLWKMGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |