Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1887 | 1887-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V | L10F, L33F, Q58E | L19I, K20R, E35D, N37E, R57K, I62V, L63AT, I64V, E65D, T74S, V77I, I85V, T91S |
| >1887-30630| codons 4-99 TLWQRPFVTIKIGGQIREALLDTGADDTIFEDMELPGRWKPKIVGGIGGFIKVKEYDQVT VDICGHKAIGSVLIGPTPVNIVGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | K219E | Y188L | T39TA, K102M, V106I, K166R, I178M, V179I, T200A, E204ED, R211K, D237E |
| >1887-30630| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKMKKSITVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDMIIYQYVDDLLVGSDLEIGQHRAKIEDLRQHLLKWGFYTP DEKHQKEPPFLWMGYELHPEKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |