Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2466 | 2466-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L33F, K43KT, F53FL, G73T | L10I, I13V, E34Q, K55KN, D60E, I62V, L63P, A71I, V77I, I85IL, I93L |
| >2466-30820| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTIFQEMNLPGRWTPKIVGGIGGLLNVRQYEQVP IEICGHKIITTVLIGPTPVNVLGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | Y181C | A98G | K43Q, E44D, V111I, D123E, I142IT, D177DE, T200A, E203K, Q207D, H208Y, R211K, K223Q |
| >2466-30820| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDIGDAYFSVPLDKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTP DRKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |