Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2257 | 2257-30818 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | V75I, F77L, F116Y, K219E | Y181C | S68G, A98S, K102KN, K122E, Q174HR, T200A, Q207E, R211K |
| >2257-30818| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHP SGLKNKKSVTVLDVGDAFYSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKRNPDIVICQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33F, T74P | L10I, V11L, I13V, K20R, E34Q, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I93L |
| >2257-30818| codons 4-99 TLWQRPILTVKIGGQLREALLDTGADDTVFQDIDLPGRWKPKMIGGIGGFLKVRQYEQVP IEICGHKVIGPVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |