Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2256 | 2256-30722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DN, K70R, L74I, M184V, T215F | K219Q | L100I, K103N | K64H, V90I, V111I, K122E, I135T, S162Y, M164L, I178IM, G196E, T200TA, E203D, V245M |
| >2256-30722| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEIQLGIPHP AGIKKNKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSLTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIEQHRAKIDELRQHLLRWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54ILM, I84V, L90M | L10F, G73S, L89V | I13V, I15V, L19Q, K20I, E35D, I62V, L63P, A71V, I72M |
| >2256-30722| codons 4-99 TLWQRPFVTVKVGGQQIEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFMKVRQYDQVP IEICGHKVMSTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |