<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2256 2256-30722 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69DN, K70R, L74I, M184V, T215F K219Q L100I, K103N   K64H, V90I, V111I, K122E, I135T, S162Y, M164L, I178IM, G196E, T200TA, E203D, V245M  
>2256-30722| codons 38-247
CTEMEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKIVDFRELNKRTQDFWEIQLGIPHP
AGIKKNKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQYSLTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIEQHRAKIDELRQHLLRWGFFTP
DQKHQKEPPFLWMGYELHPDKWTVQPIMLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54ILM, I84V, L90M L10F, G73S, L89V I13V, I15V, L19Q, K20I, E35D, I62V, L63P, A71V, I72M  
>2256-30722| codons 4-99
TLWQRPFVTVKVGGQQIEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFMKVRQYDQVP
IEICGHKVMSTVLVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006