Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1110 | 1110-30409 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, M184I, T215Y | Y188L | V179E | K43Q, K64KR, W88C, V118I, K122E, Q197K, T200E | N54NI |
| >1110-30409| codons 38-247 CTELEQEGKISKIGPEIPYNTPVFAIRKKDSSKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIEIYQYIDDLLVGSDLEIGKHREKIEELRQHLLRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, Q58E, G73T | L10I, T12TP, I13S, I15IV, K20I, L33LV, M36MI, I62V, L63P, I64IV, A71IT, I72T, V77VI, I93L |
| >1110-30409| codons 4-99 TLWQRPIIPSKVGGQLIEALLDTGADDTVVEEINLPGRWKPKIIGGIGGFVKVREYDQVP VEICGHKTTTTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |