Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1109 | 1109-30326 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33F, G73T | L10I, K20R, E35D, M36I, K43Q, I62V, L63P, I66L, C67F, H69R, A71V, I72M |
| >1109-30326| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFEDINLPGRWQPKMIGGIGGFLKVRQYDQVP IELFGRKVMTTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219KR | K103N, Y181C | K43E, V118I, K122E, I135T, I142V, G196E, R211K, L228H | L187LM |
| >1109-30326| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDMYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DRKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |