Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2048 | 2048-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10LI, T12N, L19LI, N37D, D60E, L63P, A71V, V77I, I93L |
| >2048-30819| codons 4-99 TLWQRPIVNIKIGGQIKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYEQIP IEICGHKVIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, L74LV, T215TNSY | Y181V | S68SN, K122E, D123E, I135T, S162C, Q174K, T200I, R211K, F214FL, E224ED |
| >2048-30819| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDNTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKKNPDIVIVQYMDDLYVGSDLEIGQHRIKIEELRQHLLKWGLYTP DKKHQKDPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |