Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1390 | 1390-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L33I | L10I, G16E, N37Q, P39S, R41RK, L63H, A71V, I72T, V77I, I85V, I93L |
| >1390-30813| codons 4-99 TLWQRPIVTIKIEGQLKEALLDTGADDTVIEEMQLSGKWKPKIIGGIGGFMKVRQYDQIH IEICGHKVTGTVLIGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N | K43E, V111M, V118VI, K122E, I178M, T200A, E203D, Q207E, H208Y, R211K, L228H | D113N, D177DGNS |
| >1390-30813| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDMGNAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPSMVIYQYVDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |