Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1389 | 1389-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13IM, K14KR, N37D, R57K, I62V, L63P, A71T, V77I, I93L |
| >1389-30623| codons 4-99 TLWQRPLVTMRIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVKQYDQVP IEICGHKTIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | D123E, I135IM, I142V, E169D, T200A, R211RG, V245I | D113DN |
| >1389-30623| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGNAYFSVPLDKEFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLGWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |