Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1387 | 1387-30521 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L24I, K43T | L10I, T12S, I15V, L19I, E35D, M36MIV, N37H, R41K, K55R, I62V, L63P, I66V, H69R, K70T, T74S, V77I, I93L, C95F | D29DV |
| >1387-30521| codons 4-99 TLWQRPIVSIKVGGQIKEALIDTGAVDTVLEDVHLPGKWTPKIIGGIGGFVRVRQYDQVP IEVCGRTAIGSVLIGPTPSNIIGRNLLTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V | T215V, K219Q | K103N | V179E, P225H | V118I, L120*, K122E, D123DN, E138Q, T200A, Q207E, R211K, F214L, L228H |
| >1387-30521| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIP*DENFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIEIYQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLVTP DQKHQKEHPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |