Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1385 | 1385-30512 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, V82T | L24I, F53L | L10I, T12P, Q18M, R41K, K55R, I62IV, L63P, I64V, T74S, I85V |
| >1385-30512| codons 4-99 TLWQRPIVPIKIGGMLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGLLRVRQYDQVP VEICGHKAIGSVLVGPTPTNIVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K49R, V60I, D123E, S162D, K166R, E169D, T200A, I202IV, E203D, H208HY, R211K |
| >1385-30512| codons 38-247 CTEMEKEGKISRIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTRILDPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKVDELRQYLLKWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |