Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1108 | 1108-30624 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A | L24I | L10I, I62V, L63P, H69R, A71V, I72V, V77I |
| >1108-30624| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKMIVGIGGFSKVRQYDQVP IEICGRKVVGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K70KI, F77L | T69TN, V118I, K122E, I135L, I142IT, Q145QR, S162D, R211K, L228R |
| >1108-30624| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSNIWRKLMDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGTRYRYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |