Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1107 | 1107-30617 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, I84V, L90M | V11VI, L33F, L89V | L10I, I13V, I15V, L19Q, K20R, M36I, N37S, R41K, Q61H, L63P, K70R, A71V, V82I, Q92R |
| >1107-30617| codons 4-99 TLWQRPIITVKVGGQQREALLDTGADDTIFEEISLPGKWKPKMVGGIGGFMKVRQYDHIP IEICGHRVIGTVLVGPTPINVIGRNVMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215F | K103N, M230L | K43E, D123E, I135T, S162C, K166R, D177E, G196E, T200A, E204Q, Q207E, R211K, L228R | N137H |
| >1107-30617| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNHETPGIRYQYNVLPQGWKGSP AIFQCSMTRILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRAKIEQLREHLWKWGFFTP DKKHQKEPPFRWLGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |