Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1104 | 1104-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | Y188YFHL | A98G | V60VI, V106VI, K122E, D123E, I135V, S162C, E169D, Q174E, I178L, T200A, E203ED, H208HY, V245E |
| >1104-30610| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSITVLDVGDAYFSVPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKENPDLVIYQYVDDLLVGSDLEIGQHRAKIDELRQYLLRWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | Q58E, G73S | L10I, T12K, I15V, L19P, K20I, E34Q, M36I, L63P, A71V, I85V |
| >1104-30610| codons 4-99 TLWQRPIVKIKVGGQPIEALLDTGADDTVLQEINLPGRWKPKIVGGIGGFMKVREYDQIP IEICGHKVISTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |