Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1105 | 1105-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I84V, L90M | L10I, E34EG, L63LP, I64V, I66IV, A71AV, T74TA |
| >1105-30610| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLGEMNLPGRWKPKLIGGIGGFIKVRQYDQIP VEVCGHKVIGAVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | D67DG, K219KN | G190GE | S68SG, V118VI, K122E, S134SG, Q207E, R211K | P59PS |
| >1105-30610| codons 38-247 CTELEKEGKISKIGPENPYNTSVFAIKKKGGTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPGINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVESDLEIGQHRTKIEELREHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |