Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1383 | 1383-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33F | L10I, G16A, I62V, L63P, I64L, A71T, V77I, Q92K, I93L |
| >1383-30507| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVRQYDQVP LEICGHKTIGTVLIGPTPVNVIGRNLMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K70S, K219Q | M230L | V179D | T39A, E40F, K43E, K103R, K104KR, V111I, D123E, S162SA, I167V, G196E, Q207E, H208HY, R211K, V245M |
| >1383-30507| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSTSWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKRRSVTVLDIGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQASMTKVLEPFRKQNPDIDIYQYVDDLYVGSDLEIEQHRTKIEELREYLWKWGFYTP DQKHQKEPPFLWLGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |